Associations between mitochondrial copy number, exercise capacity, physiologic cost of walking, and cardiac strain in young adult survivors of childhood cancer.

Amy M BerkmanChelsea G GoodenoughPaul DurakiewiczCarrie R HowellZhaoming WangJohn EastonHeather L MulderGregory T ArmstrongMelissa M HudsonMondira KunduKirsten K Ness

Published in: Journal of cancer survivorship : research and practice (2024)

These findings demonstrate a potential role for mtDNA-CN as a biomarker of early cardiac dysfunction in this population.

Keyphrases

copy number
childhood cancer
young adults
mitochondrial dna
oxidative stress
genome wide
left ventricular
dna methylation
high intensity
lymph node metastasis
physical activity
heart failure
gene expression
lower limb
atrial fibrillation