Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients.
Michaela MuellerRui E CastroAnders ThorellHanns-Ulrich MarschallNicole AuerMerima HeracCecilia M P RodriguesMichael TraunerPublished in: Liver international : official journal of the International Association for the Study of the Liver (2017)
Our data suggest that UDCA treatment has ambivalent effects in NAFLD patients. While increased SAF-scores and elevated CHOP levels may be disadvantageous in the UDCA treated cohort, UDCA's cytoprotective properties potentially changed the apoptotic threshold as reflected by absent induction of pro-apoptotic triggers. UDCA treatment failed to improve the oxidative stress status in NAFLD patients.
Keyphrases
- oxidative stress
- obese patients
- end stage renal disease
- newly diagnosed
- cell death
- bariatric surgery
- ejection fraction
- chronic kidney disease
- prognostic factors
- endoplasmic reticulum stress
- peritoneal dialysis
- dna damage
- ischemia reperfusion injury
- signaling pathway
- small molecule
- induced apoptosis
- roux en y gastric bypass
- artificial intelligence
- combination therapy
- diabetic rats