p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma.

Shufang JinXi YangJiayi LiWenyi YangHai-Long MaZhiyuan Zhang

Published in: Molecular cancer (2019)

Our results revealed the transcriptional regulation of lincRNA-p21 by the mutant p53/NF-YA complex in HNSCC. LincRNA-p21 acted as a tumor suppressor in HNSCC progression, which was attributed to direct binding to STAT3 and blocking of JAK2/STAT3 signaling.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
cell proliferation
cancer therapy
oxidative stress
lps induced
single cell
immune response
nuclear factor
drug delivery
toll like receptor