Fungal-induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL-22.
Yanan ZhuTao ShiXia LuZhen XuJunxing QuZhiyong ZhangGuoping ShiSunan ShenYayi HouYugen ChenTingting WangPublished in: The EMBO journal (2021)
Incorporation of microbiome data has recently become important for prevention, diagnosis, and treatment of colorectal cancer, and several species of bacteria were shown to be associated with carcinogenesis. However, the role of commensal fungi in colon cancer remains poorly understood. Here, we report that mice lacking the c-type lectin Dectin-3 (Dectin-3-/- ) show increased tumorigenesis and Candida albicans burden upon chemical induction. Elevated C. albicans load triggered glycolysis in macrophages and interleukin-7 (IL-7) secretion. IL-7 induced IL-22 production in RORγt+ (group 3) innate lymphoid cells (ILC3s) via aryl hydrocarbon receptor and STAT3. Consistently, IL-22 frequency in tumor tissues of colon cancer patients positively correlated with fungal burden, indicating the relevance of this regulatory axis in human disease. These results establish a C. albicans-driven crosstalk between macrophages and innate lymphoid cells in the intestine and expand our understanding on how commensal mycobiota regulate host immunity and promote tumorigenesis.
Keyphrases
- candida albicans
- induced apoptosis
- cell cycle arrest
- biofilm formation
- endothelial cells
- gene expression
- diabetic rats
- single cell
- transcription factor
- oxidative stress
- cell proliferation
- cell death
- pseudomonas aeruginosa
- electronic health record
- skeletal muscle
- deep learning
- signaling pathway
- big data
- genetic diversity
- artificial intelligence