Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway.

Carolina Petri Bernardes Ernesto Lopes Pinheiro-JuniorIsabela Gobbo FerreiraIsadora Sousa de OliveiraNeife Aparecida Guinaim Dos SantosSuely Vilela SampaioEliane Candiani Arantes Antonio Cardozo Dos Santos

Published in: The journal of venomous animals and toxins including tropical diseases (2024)

These findings show, for the first time, that crotapotin has neurotrophic/neuroprotective/neurorestorative potential and might be beneficial in Parkinson's disease. Additional studies are necessary to evaluate the toxicity of crotapotin in other cell models.

Keyphrases

signaling pathway
oxidative stress
pi k akt
single cell
epithelial mesenchymal transition
cell therapy
growth factor
induced apoptosis
oxide nanoparticles
stem cells
human health
cell proliferation
bone marrow
brain injury