A complex systems model of breast cancer etiology: The Paradigm II Model.
Robert A HiattLee WordenDavid RehkopfNatalie EngmannMelissa TroesterJohn S WitteKaya BalkeChristian JacksonJanice BarlowSuzanne E FentonSarah GehlertRoss A HammondGeorge KaplanJohn KornakKrisida NishiokaThomas McKoneMartyn T SmithLeonardo TrasandeTravis C PorcoPublished in: PloS one (2023)
The Paradigm II model illustrates the role of multiple etiologic factors in breast cancer from domains of biology, behavior and the environment. The value of the model is in providing a virtual laboratory to evaluate a wide range of potential interventions into the social, environmental and behavioral determinants of breast cancer at the population level.