TrkC Is Essential for Nephron Function and Trans-Activates Igf1R Signaling.

Carolin LepaSascha HoppeAntje StöberBoris V SkryabinLaura Katharina SieversBarbara HeitplatzGiuliano CiarimboliUte NeugebauerMaja T LindenmeyerClemens D CohenHannes C A DrexlerPeter BoorThomas WeideHermann PavenstädtBritta George

Published in: Journal of the American Society of Nephrology : JASN (2020)

Our results show that TrkC is essential for maintaining glomerular integrity. Furthermore, TrkC modulates Igf-related signaling in podocytes.

Keyphrases

binding protein
diabetic nephropathy
pi k akt
high glucose
growth hormone
cell proliferation