Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in HSCs.

Cheng SunChan ZhouKaveh DaneshvarAmel Ben SaadArcadia J KratkiewiczBenjamin J TolesNahid ArghianiAnja HessJennifer Y ChenJoshua V PondickSamuel R YorkWenyang LiSean P MoranStefan D GentileRaza Ur RahmanZixiu LiPeng ZhouRobert P SparksTim HabboubByeong-Moo KimMichael Y ChoiSilvia AffoRobert F SchwabeYury V PopovAlan C Mullen

Published in: Hepatology (Baltimore, Md.) (2024)

TILAM is activated in HSCs with liver injury and interacts with promyelocytic leukemia nuclear body scaffold protein to drive the development of fibrosis. Depletion of TILAM may serve as a therapeutic approach to combat the development of end-stage liver disease.

Keyphrases

liver fibrosis
liver injury
long noncoding rna
drug induced
acute myeloid leukemia
bone marrow
transcription factor
amino acid
protein protein