ARCHE-NOAH: NMR supersequence with five different CEST experiments for studying protein conformational dynamics.

Rodrigo Cabrera Allpas Alexandar L Hansen Rafael Brüschweiler

Published in: Physical chemistry chemical physics : PCCP (2023)

An NMR NOAH-supersequence is presented consisting of five CEST experiments for studying protein backbone and side-chain dynamics by 15 N-CEST, carbonyl- 13 CO-CEST, aromatic- 13 C ar -CEST, 13 C α -CEST, and methyl- 13 C met -CEST. The new sequence acquires the data for these experiments in a fraction of the time required for the individual experiments, saving over four days of NMR time per sample.

Keyphrases

electronic health record
magnetic resonance
high resolution
amino acid
solid state
binding protein
molecular dynamics
mass spectrometry
protein protein
single molecule
deep learning