Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor.

Mohammed S Al SuraihChristy E TrussoniPatrick L SplinterNicholas F LaRusso Steven P O'Hara

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

The data continue to support the importance of cholangiocyte senescence in PSC pathogenesis, directly implicate EVs in cholangiocyte proliferation, malignant progression and immune cell activation and migration, and identify novel therapeutic approaches for PSC.

Keyphrases

epidermal growth factor receptor
tyrosine kinase
advanced non small cell lung cancer
single cell
electronic health record
signaling pathway
dna damage
endothelial cells
big data
stem cells
stress induced
oxidative stress
bone marrow