A new and potentially prebiotic α-cytidine derivative.
Maria TsanakopoulouJianfeng XuAndrew D BondJohn D SutherlandPublished in: Chemical communications (Cambridge, England) (2018)
A new α-cytidine derivative was synthesised from the prebiotic reaction of ribose aminooxazoline and dicyanoacetylene. The tetracyclic structure of the product was confirmed by X-ray diffraction and then an alternative 6-step synthetic pathway to the product was found which was suitable for large-scale synthesis.