Are High Levels of Microsatellite Instability and Microsatellite Stability Identical in DNA Mismatch Repair-Deficient Colorectal Cancer Patients?

Published in: Canadian journal of gastroenterology & hepatology (2023)

The MSI-H status was associated with colon cancer and a lower mutation rate of the KRAS gene in DMMR patients. In CRC-DMMR patients, the MSS group exhibited better OS and DFS than the MSI-H group, although these differences were not statistically significant. Accordingly, in clinical practice, we should not confuse these two types of patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
clinical practice
gene expression
transcription factor
single molecule
patient reported
genetic diversity