Supporting cell survival after cochlear implant surgery.
Alvin DeTorresRafal T OlszewskiIvan A LopezAkira IshiyamaFred H LinthicumMichael HoaPublished in: The Laryngoscope (2018)
Supporting cells (SCs) provide structure and maintain an environment that allows hair cells to receive and transmit signals in the auditory pathway. After insult to hair cells and ganglion cells, SCs respond by marking unsalvageable cells for death and maintain structural integrity. Although the histopathology after cochlear implantation has been described regarding hair cells and neural structures, surviving SCs in the implanted ear have not. We present a patient whose posthumous examination of an implanted cochlea demonstrated SC survival. This finding has implications for SC function in maintaining electrical hearing and candidacy for future hair cell regeneration therapies. Laryngoscope, 129:E36-E40, 2019.
Keyphrases
- induced apoptosis
- cell cycle arrest
- stem cells
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- minimally invasive
- cell death
- acute coronary syndrome
- mass spectrometry
- mesenchymal stem cells
- coronary artery disease
- spinal cord
- working memory
- percutaneous coronary intervention
- cell proliferation
- wound healing