Non-Cell Autonomous Epileptogenesis in Focal Cortical Dysplasia.

Hyun Yong KohJaeson JangSang Hyeon JuRyunhee KimGyu-Bon ChoDong Seok KimJong-Woo SohnSe-Bum PaikJeong Ho Lee

Published in: Annals of neurology (2021)

This study shows that neurons carrying somatic mutations in MTOR lead to focal epileptogenesis via non-cell-autonomous hyperexcitability of nearby nonmutated neurons. ANN NEUROL 2021;90:285-299.

Keyphrases

single cell
cell therapy
spinal cord
cell proliferation