Proteomic profiling for detection of early-stage heart failure in the community.
Nicholas CauwenberghsFrantišek SabovčikAlessio MagnusFrancois HaddadTatiana KuznetsovaPublished in: ESC heart failure (2021)
We identified proteins related to renal function, extracellular matrix remodelling, angiogenesis, and inflammation to be associated with echocardiographic signs of early-stage heart failure. Proteomic phenomapping discriminated individuals at high risk for cardiac remodelling and dysfunction.
Keyphrases
- early stage
- extracellular matrix
- heart failure
- left ventricular
- label free
- oxidative stress
- cardiac resynchronization therapy
- sentinel lymph node
- acute heart failure
- healthcare
- endothelial cells
- atrial fibrillation
- single cell
- pulmonary hypertension
- vascular endothelial growth factor
- squamous cell carcinoma
- radiation therapy
- lymph node
- drug induced