A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa.
Louisa A HoJudith L WinogrodzkiAleksandra W DebowskiZarina MaddenDavid J VocadloBrian L MarkKeith A StubbsPublished in: Chemical communications (Cambridge, England) (2018)
The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC β-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important β-lactams against a clinically relevant strain of Pseudomonas aeruginosa.