The brain-immune cells axis controls tissue specific immunopathology.
Maxi HeynerSarah SchreierAndrea KrögerPublished in: Cellular & molecular immunology (2018)
During viral infections, cell death can be induced as a direct result of cytopathic virus replication in various cell types and tissues or as an immune response of the host to the infectious agent. This leads to an infiltration of inflammatory cells, causing subsequent tissue damage. The balance between effective elimination of the pathogen and prevention of fatal tissue damage is decisive for life. The host has developed various mechanisms to inhibit excessive immune responses.
Keyphrases
- immune response
- cell death
- oxidative stress
- cell cycle arrest
- induced apoptosis
- diabetic rats
- dendritic cells
- toll like receptor
- sars cov
- gene expression
- high glucose
- single cell
- weight gain
- white matter
- resting state
- pi k akt
- candida albicans
- endoplasmic reticulum stress
- cell proliferation
- multiple sclerosis
- body mass index
- signaling pathway
- functional connectivity
- subarachnoid hemorrhage
- endothelial cells
- disease virus