Specific ablation of PDGFRβ-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models.

Seok Jae Lee Soohyun KimDong Hyun JoChang Sik ChoSu Ree KimDongmin KangJisu ChaeDuck Kyun YooSuji HaJunho ChungJeong Hun Kim

Published in: Communications medicine (2021)

Our results suggest that removing PDGFRβ-expressing pericytes by an ADC targeting PDGFRβ could be a potential therapeutic strategy for pathologic ocular neovascularization.

Keyphrases

neoadjuvant chemotherapy
vascular endothelial growth factor
diabetic retinopathy
mouse model
cancer therapy
locally advanced
diffusion weighted
diffusion weighted imaging
drug delivery
computed tomography
rectal cancer
radiation therapy
contrast enhanced