Aza-[4 + 2] cycloadditions employing catalytically derived <i>N</i>-acyliminium ions.
Niamh J OwenMark G McLaughlinPublished in: Organic & biomolecular chemistry (2022)
Herein, we report the development of a novel route to tricyclic lactam products <i>via</i> a facile aza-[4 + 2] cycloaddition of catalytically generated acyliminium ions. Employing a Ca(NTf<sub>2</sub>)<sub>2</sub>/<i>n</i>Bu<sub>4</sub>NPF<sub>6</sub> catalyst system in low loadings, a range of diverse fused ring systems can be synthesised in predominantly good yields.