A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome.
S ThalmanKathryn Lacey O'ConnorA-L LinN F JohnsonG JichaA Caban-HoltW RobertsonD LightnerD PowellE HeadF SchmittPublished in: Journal of intellectual disability research : JIDR (2020)
This preliminary study of CBF in DS indicates that cerebrovascular pathology may be a significant contributor to dementia in DS. CBF was associated with diagnosis, cognition and age. Notably, CBF decreases at a greater rate after age 45 and may represent a significant prodromal event in AD progression.