Maternal High-Fat Diet Programs Renal Peroxisomes and Activates NLRP3 Inflammasome-Mediated Pyroptosis in the Rat Fetus.
Pei ZhouHongbo GuanYanyan GuoLiangliang ZhuXiaomei LiuPublished in: Journal of inflammation research (2021)
A maternal high fat diet decreased the number of peroxisomes, subsequently activated OS and inflammasomes, resulting in pyroptosis and apoptosis in fetal kidney. The antioxidant PQQ served a protective role against the effects of lipotoxicity on kidney programming and, thus, is a potential candidate to prevent maternal obesity-induced renal programming.
Keyphrases
- high fat diet
- nlrp inflammasome
- insulin resistance
- adipose tissue
- birth weight
- oxidative stress
- pregnancy outcomes
- metabolic syndrome
- weight gain
- type diabetes
- diabetic rats
- skeletal muscle
- high fat diet induced
- weight loss
- public health
- gestational age
- high glucose
- cell cycle arrest
- risk assessment
- pregnant women
- drug induced
- body mass index
- endothelial cells