Dual Photoredox/Nickel-Catalyzed Dehydrative Difluoroalkylation of Benzyl Alcohols for the Synthesis of Allylic gem -Difluorides.

A photoredox/Lewis acid cooperative catalytic system has been developed for the construction of C vinyl -C Rf bonds through the dehydrative difluoroalkylation of benzyl alcohols. A variety of allylic gem -difluorides could be obtained in moderate yields with good to excellent E / Z selectivity. In addition, several control experiments have been explored, and a possible mechanism was proposed for this process.