Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism.

Meichao MenDan-Na ChenJia-Da LiXinying WangWang ZengFang JiangRuizhi ZhengWenting Dai

Published in: Molecular genetics & genomic medicine (2021)

Our study greatly enriched the genotypic and phenotypic spectra of PLXNA1, NRP1, and NRP2 in IHH. It may be conducive to the genetic counseling, diagnosis, and treatment of IHH with mutations in the PLXNA1, NRP1, and NRP2 genes. Furthermore, our results indicated that NRP1 were strongly linked to hearing loss.

Keyphrases

genome wide
hearing loss
transcription factor
molecular dynamics
replacement therapy
antiretroviral therapy
genome wide identification