MARVELD3 inhibits the epithelial-mesenchymal transition and cell migration by suppressing the Wnt/β-catenin signaling pathway in non-small cell lung cancer cells.
Shirong LiSaiping QiYanmeng LiChunpan ZhangLan SunChun-Quan LiuHao-Yan WangPublished in: Thoracic cancer (2023)
TGF-β1 induced EMT in human NSCLC cells can be suppressed by MARVELD3 through Wnt/β-catenin signaling pathway. These results indicate that MARVELD3 might be a potential therapeutic modality useful in the treatment of NSCLC.
Keyphrases
- epithelial mesenchymal transition
- cell migration
- transforming growth factor
- small cell lung cancer
- endothelial cells
- induced apoptosis
- cell proliferation
- stem cells
- advanced non small cell lung cancer
- high glucose
- signaling pathway
- cell cycle arrest
- single cell
- cell therapy
- diabetic rats
- brain metastases
- cell death
- endoplasmic reticulum stress
- combination therapy
- pi k akt
- tyrosine kinase
- replacement therapy