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DNA damage and repair on hematopoietic stem cells: impact of oxidative stress in renovascular hypertension.

Giselle S MeirelesRafaela AiresLarissa Z CôcoEdgar H KampkeMaria Es BarrosoElisardo C VasquezThiago Mc PereiraSilvana S MeyrellesBianca Prandi Campagnaro
Published in: Clinical and experimental hypertension (New York, N.Y. : 1993) (2022)
Our data imply that RH can compromise the hematopoiesis by increased oxidative stress leading to impaired DNA repair activity. Furthermore, this study provides new insights into the influence of hypertension on bone marrow homeostasis. This study showed for the first time that RH leads to oxidative damage, including genotoxic, to bone marrow cells. Thus, these findings provide new insights into the consequences of RH on bone marrow cells.
Keyphrases
  • induced apoptosis
  • bone marrow
  • dna damage
  • oxidative stress
  • dna repair
  • cell cycle arrest
  • mesenchymal stem cells
  • blood pressure
  • endoplasmic reticulum stress
  • signaling pathway
  • cell proliferation
  • dna damage response