MS-Driven Metabolic Alterations Are Recapitulated in iPSC-Derived Astrocytes.
Bruno GhirottoDanyllo F OliveiraMarcella CipelliPaulo José BassoJean DE LimaCristiane Naffah de Souza BredaHenrique C RibeiroCamille C C SilvaAndrea Laurato SertiéAntonio Edson R OliveiraMeire I HiyaneElia Tamaso Espin Garcia CaldiniAlessandra SussuliniHelder Takashi Imoto NakayaAlicia J KowaltowskiEnedina Maria Lobato de OliveiraMayana ZatzNiels Olsen Saraiva CamaraPublished in: Annals of neurology (2022)
Here we describe the metabolic profile of iPSC-derived astrocytes from PwMS and validate this model as a very powerful tool to study disease mechanisms and to perform non-invasive drug targeting assays in vitro. Our findings recapitulate several disease features described in patients and provide new mechanistic insights into the metabolic rewiring of astrocytes in MS, which could be targeted in future therapeutic studies. ANN NEUROL 2022;91:652-669.