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Blood donor-derived buffy coat to produce platelets in vitro.

Irene MariniFlavianna RigoniJan ZlamalLisann PelzlKarina AlthausStefanie Nowak-HarnauMatthew T RondinaTamam Bakchoul
Published in: Vox sanguinis (2019)
Haematopoietic progenitor cells isolated from buffy coat have increased yield of platelets released from mature megakaryocytes and enhanced in vitro functionality, compared with peripheral blood-derived cells. Our study, suggests that buffy coat, obtained during blood donation processing, might be a promising source of megakaryocytes for in vitro platelet production.
Keyphrases
  • peripheral blood
  • induced apoptosis
  • cell cycle arrest
  • oxidative stress
  • cell proliferation