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Superior protective effects of PGE2 priming mesenchymal stem cells against LPS-induced acute lung injury (ALI) through macrophage immunomodulation.

Kamal HezamChen WangEnze FuManqian ZhouYue LiuHui WangLihong ZhuZhibo HanZhong-Chao HanYing ChangZongjin Li
Published in: Stem cell research & therapy (2023)
PGE2-MSC therapy significantly reduced the severity of LPS-induced ALI in mice by modulating macrophage polarization and cytokine production. This strategy boosts the therapeutic efficacy of MSCs in cell-based ALI therapy.
Keyphrases
  • lps induced
  • inflammatory response
  • mesenchymal stem cells
  • cell therapy
  • umbilical cord
  • lipopolysaccharide induced
  • single cell
  • adipose tissue
  • type diabetes
  • signaling pathway
  • stem cells
  • insulin resistance