Progression from Prodromal Alzheimer's Disease to Mild Alzheimer's Disease Dementia in the Verubecestat APECS Study: Adjudicating Diagnostic Transitions.
Tiffini VossJames KostSwati Pal MercerChristine FurtekChristopher RandolphChristopher LinesMichael F EganJeffrey L CummingsPublished in: Journal of Alzheimer's disease : JAD (2023)
A positive Site Investigator opinion is an excellent predictor for a positive adjudication decision regarding onset of dementia. Conversely, sole use of CDR sum-of-boxes change ≥2 is inadequate. The benefit of centralized adjudication appears doubtful.