Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model.
Xiao-Fei HeGe LiLi-Li LiMing-Yue LiFeng-Yin LiangXi ChenXi-Quan HuPublished in: Molecular brain (2020)
Our results strongly suggest that overexpression of Slit2 protected against the dysfunction in MIs, which is a potential therapeutic target for cognition impairment in the elderly.