Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ.

Ildar V GainetdinovYulia V SkvortsovaSofia A KondratievaAlexey KlimovAlexey A TryakinTatyana L Azhikina

Published in: BMC cancer (2018)

Though further studies are warranted, these findings suggest that the conventional germline-like PIWI/piRNA pathway is lost in transition from germ cells to GCNIS cells.

Keyphrases

germ cell
induced apoptosis
cell cycle arrest
oxidative stress
signaling pathway
high grade
dna repair
dna damage