Gene fusion of IL7 involved in the regulation of idiopathic pulmonary fibrosis.
Shixue SunChen HuangDongliang LengChang ChenTeng ZhangKuan Cheok LeiXiaohua Douglas ZhangPublished in: Therapeutic advances in respiratory disease (2021)
Based on the results, we conclude that IL7 = AC083837.1 gene fusion might exacerbate fibrosis in IPF via enhancing activities of natural killer cell-mediated cytotoxicity, skin cell apoptosis, and vessel angiogenesis, the interaction of which contributes to the development of fibrosis and the deterioration of respiratory function of IPF patients. Our work unveils the possible roles of gene fusion in regulating IPF and demonstrates that gene fusion investigation is a valid approach in probing immunologic mechanisms and searching potential therapeutic targets for treating IPF.The reviews of this paper are available via the supplemental material section.
Keyphrases
- idiopathic pulmonary fibrosis
- copy number
- genome wide
- interstitial lung disease
- end stage renal disease
- newly diagnosed
- stem cells
- systematic review
- cell proliferation
- prognostic factors
- endothelial cells
- ejection fraction
- peritoneal dialysis
- cell therapy
- systemic sclerosis
- dna methylation
- molecular dynamics simulations
- soft tissue
- meta analyses