Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells.
Adam J LinleyLaura I KarydisAnil Kumar MondruAnnalisa D'AvolaHumood Al ShmranySilvia CicconiRebecca GriffinFrancesco ForconiAndrew R PettittNagesh KalakondaAndrew C RawstronPeter HillmenAndrew J SteeleDavid J MacEwanGraham PackhamIan A PriorJoseph R SlupskyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
These data comprise the first comprehensive proteomic investigation of the BCR signaling response within CLL cells and reveal unique evidence that these cells undergo adaptive reprogramming of this signaling in response to therapy.