Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy.

Revital SchickLucy N MekiesYuval ShemerBinyamin EisenTova HallasRonen Ben JehudaMeital Ben-AriAgnes SzantaiLubna WilliRita ShulmanMichael GramlichLuna Simona PaneIlaria MyDov FreimarkMarta MurgiaGianluca SantamariaMihaela GherghiceanuMichael AradAlessandra MorettiOfer Binah

Published in: PloS one (2018)

These findings show that the mutated cardiomyocytes from DCM patients recapitulate abnormalities of the inherited cardiomyopathies, expressed as blunted inotropic response.

Keyphrases

high glucose
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
patient reported outcomes