Endoplasmic Reticulum Stress, Oxidative Stress, and Rheumatic Diseases.
Bruna Miglioranza ScavuzziJoseph HoloshitzPublished in: Antioxidants (Basel, Switzerland) (2022)
Loss of ER homeostasis is a significant factor in the pathogeneses of RA and SLE. Targeting ER stress, unfolded protein response (UPR) pathways and oxidative stress in these diseases both in vitro and in animal models have shown promising results and deserve further investigation.
Keyphrases
- endoplasmic reticulum stress
- induced apoptosis
- oxidative stress
- disease activity
- systemic lupus erythematosus
- dna damage
- diabetic rats
- rheumatoid arthritis
- ischemia reperfusion injury
- endoplasmic reticulum
- estrogen receptor
- protein protein
- cancer therapy
- signaling pathway
- ankylosing spondylitis
- breast cancer cells
- amino acid
- small molecule
- heat shock
- systemic sclerosis