Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035.
Xiuli XuYifei DongJinpeng YangLong WangLinlin MaFu-Hang SongXiaoli MaPublished in: Journal of fungi (Basel, Switzerland) (2024)
Two new polyketide derivatives, penirubenones A and B ( 1 and 2 ), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B ( 3 and 4 ), together with nine known compounds ( 5 - 13 ) were isolated from the marine-derived fungus Penicillium rubens BTBU20213035. The structures were identified by HRESIMS and 1D and 2D NMR analyses, and their absolute configurations were determined by a comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy and 13 C NMR data. We found that 6 exhibited antibacterial activity against Staphylococcus aureus , with an MIC value of 3.125 μg/mL, and 1 and 2 showed synergistic antifungal activity against Candida albicans at 12.5 and 50 μg/mL with 0.0625 μg/mL rapamycin.
Keyphrases
- candida albicans
- high resolution
- biofilm formation
- solid state
- staphylococcus aureus
- magnetic resonance
- ms ms
- structure activity relationship
- electronic health record
- big data
- mass spectrometry
- single molecule
- pseudomonas aeruginosa
- cancer therapy
- machine learning
- cystic fibrosis
- drug delivery
- data analysis
- deep learning