Truncating Variants in OBSCN Gene Associated With Disease-Onset and Outcomes of Hypertrophic Cardiomyopathy.

Guixin Wu Jie LiuMinghao LiuQiya HuangJieyun RuanChanna ZhangDong WangXiaolu SunWen JiangLianming KangJi-Zheng Wang Lei Song

Published in: Circulation. Genomic and precision medicine (2021)

Our data indicated that OBSCN truncating variants contributed to the disease-onset of HCM, and increased the risk of malignant events in patients with HCM.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
copy number
heart failure
genome wide
gene expression
big data
adipose tissue
atrial fibrillation
transcription factor