Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics.
Alexandra TauzinLorie MarchittoÉtienne BélangerMehdi BenlarbiGuillaume Beaudoin-BussièresJérémie PrévostDerek YangTa-Jung ChiuHung-Ching ChenCatherine BourassaHalima MedjahedMarek K KorzeniowskiSuneetha GottumukkalaWilliam D TolbertJonathan RichardAmos B SmithMarzena E PazgierAndrés FinziPublished in: Journal of virology (2024)
There are several reasons that make it difficult to target the HIV reservoir. One of them is the capacity of infected cells to prevent the recognition of HIV-1 envelope glycoproteins (Env) by commonly elicited antibodies in people living with HIV. Small CD4-mimetic compounds expose otherwise occluded Env epitopes, thus enabling their recognition by non-neutralizing antibodies (nnAbs). A better understanding of the contribution of these antibodies to eliminate infected cells in the presence of CD4mc could lead to the development of therapeutic cure strategies.
Keyphrases
- induced apoptosis
- antiretroviral therapy
- hiv positive
- hiv infected
- human immunodeficiency virus
- cell cycle arrest
- hepatitis c virus
- hiv testing
- nk cells
- hiv aids
- men who have sex with men
- oxidative stress
- endoplasmic reticulum stress
- high glucose
- cell death
- cell proliferation
- signaling pathway
- zika virus
- dengue virus
- south africa
- pi k akt