Transglycosylation products generated by Talaromyces amestolkiae GH3 β-glucosidases: effect of hydroxytyrosol, vanillin and its glucosides on breast cancer cells.
Juan Antonio Méndez-LíterIsabel TundidorManuel Nieto-DomínguezBeatriz Fernández de ToroAndrés González SantanaLaura Isabel de EugenioAlicia PrietoJuan Luis AsensioFrancisco Javier CañadaCristina SánchezMaria Jesus MartinezPublished in: Microbial cell factories (2019)
GH3 β-glucosidases from T. amestolkiae expressed in P. pastoris were able to transglycosylate a wide variety of acceptors. Between them, phenolic molecules like hydroxytyrosol, vanillin alcohol, 4-hydroxybenzyl alcohol, and hydroquinone were the most suitable for its interesting biological properties. The glycosides of hydroxytyrosol and vanillin were tested, and they improved the biological activities of the original aglycons on breast cancer cells.