Bauhinia forficata link extract attenuates insulin resistance by preserving glucose uptake in gastrocnemius muscle.
Patricia GaspariniIngrid Candido GarofoloMônica Marques TellesLila Missae OyamaViviane de Mello VenezaThiago André Moura VeigaVera Lucia Flor SilveiraLuciana Chagas CaperutoPublished in: Natural product research (2022)
Bioactive metabolites from Bauhinia forficata Link (Bf extract) hold therapeutic potential for type 2 diabetes mellitus (T2DM) but the mechanism remains poorly understood. This study aimed to test the extract from Bf leaves obtained by decoction on the prevention of T2DM in vivo . The Bf extract was tested on a streptozotocin-induced T2DM mouse model fed on a high-fat diet. The insulin resistance was attenuated in T2DM animals supplemented with Bf extract, which indicates glucose intolerance reduction and p-AKT/AKT ratio preservation in the gastrocnemius muscle. These observations suggested that Bf extract enhanced glucose uptake. Nevertheless, there was no preservation in β-cell insulin secretion in Bf extract-treated T2DM mice. Interestingly, the Bf extract reduced body weight gain without affecting total energy intake. Hence, Bf extract has a hypoglycemic effect which could attenuate the development of insulin resistance.
Keyphrases
- high fat diet
- insulin resistance
- oxidative stress
- weight gain
- anti inflammatory
- adipose tissue
- skeletal muscle
- mouse model
- type diabetes
- metabolic syndrome
- glycemic control
- high fat diet induced
- body mass index
- cell proliferation
- polycystic ovary syndrome
- signaling pathway
- stem cells
- blood glucose
- endothelial cells
- birth weight
- cardiovascular risk factors