Aescin and diosmin each alone or in low dose- combination ameliorate liver damage induced by carbon tetrachloride in rats.

Sara Mahmmoud El-DakhlyAbeer Abdallah Ali Salama Soha Osama Mahmoud Hassanin Noha Nazeeh YassenAlaaeldin Ahmed HamzaAmr Amin

Published in: BMC research notes (2020)

Results indicated that CCl4 elevated serum levels of all assessed liver function markers and decreased levels of key antioxidants. Administration of AES and/or DIO significantly reversed all those CCl4-induced effects. Histopathological study showed disruption of the hepatic architecture, necrosis and inflammatory cells and depositions of glycogen and protein in the tissues of CCl4-treated group. Pretreatment with DIO and/or AES significantly improved histopathological structure of liver tissue. In conclusion, low-dose combination of AES and DIO exhibited significant and preferential hepatoprotective activity compared to individual treatment with AES or DIO.

Keyphrases

low dose
liver injury
drug induced
liver fibrosis
high dose
oxidative stress
induced apoptosis
gene expression
cell cycle arrest
diabetic rats
high glucose
cell death
cell proliferation
small molecule
endoplasmic reticulum stress
endothelial cells