Mdka produced by the activated HSCs drives bipotential progenitor cell redifferentiation during zebrafish biliary-mediated liver regeneration.

Xintao Zhang Huijuan Liu Pengcheng Cai Zhuofu Huang Jianlong Ma Lingfei Luo

Published in: Hepatology (Baltimore, Md.) (2024)

The activated HSCs produce Mdka to drive the redifferentiation process of BP-PCs through activating Erk1 during the biliary-mediated liver regeneration, implying previously unappreciated contributions of nonparenchymal cells to this regeneration process.

Keyphrases

stem cells
signaling pathway
induced apoptosis
wound healing
cell cycle arrest
cell proliferation
endoplasmic reticulum stress