Impact of medication on blood transcriptome reveals off-target regulations of beta-blockers.

Michael RodeKolja NenoffKerstin WirknerKatrin HornAndrej TerenRalf RegenthalMarkus LoefflerJoachim ThieryAchim AignerJanne Pott Holger KirstenMarkus Scholz

Published in: PloS one (2022)

Our developed catalogue of blood gene expressions profiles affected by medication can be used to support both, drug repurposing and the identification of possible off-target effects.

Keyphrases

adverse drug
genome wide
healthcare
gene expression
single cell
copy number
angiotensin converting enzyme
emergency department
electronic health record
genome wide identification
drug discovery