Validation of NRG oncology/RTOG-0129 risk groups for HPV-positive and HPV-negative oropharyngeal squamous cell cancer: Implications for risk-based therapeutic intensity trials.

Carole A FakhryQiang ZhangMaura L GillisonPhuc Felix Nguyen-TânDavid I RosenthalRandal S WeberLouise LambertAndy M TrottiWilliam L BarrettWade L ThorstadSue S YomStuart J WongJohn A RidgeShyam S D RaoSharon SpencerAndre FortinDavid RabenJonathan HarrisQuynh-Thu Le

Published in: Cancer (2019)

RTOG-0129 risk groups persisted at 5 years and were reproducible in RTOG-0522. However, there was variability in the estimates. These data underscore the importance of long-term follow-up and appropriate patient selection in therapeutic deintensification trials.

Keyphrases

squamous cell
high grade
palliative care
case report
machine learning
big data
papillary thyroid
deep learning
data analysis