Adult-onset type 1 diabetic patients with less severe clinical manifestation have less risk DR-DQ genotypes than childhood-onset patients.
Wenqian RenDaizhi YangZiyu JiangYingxin XianQianwen HuangSihui LuoXueying ZhengJinhua YanWen XuBin YaoCong-Yi WangJin-Xin BeiLeif GroopJanelle A NobleJian-Ping WengPublished in: Diabetes/metabolism research and reviews (2020)
Adult-onset type 1 diabetic patients with susceptible haplotypes (DR3, DR4 or DR9) were more likely to carry protective DR-DQ haplotypes than childhood-onset patients, which suggested the association between less risk DR-DQ genotypes and the less severe clinical manifestation in adult-onset patients.