T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma.
Xuefeng WangJameel MuzaffarKedar S KirtaneFeifei SongMatthew JohnsonMichael J SchellJiannong LiSean J YoderJose R Conejo-GarciaJose A Guevara-PatinoMarcelo BonomiPriyanka BhatejaJames W RoccoConor E SteuerNabil F SabaChristine H ChungPublished in: Journal for immunotherapy of cancer (2022)
Our data suggest that, despite the great clinical heterogeneity of HNSCC and the limited responders in the present cohort, the peripheral TCR repertoires from pretreatment PBMC may be developed as biomarkers for the benefit of immunotherapy in HNSCC.