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T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma.

Xuefeng WangJameel MuzaffarKedar S KirtaneFeifei SongMatthew JohnsonMichael J SchellJiannong LiSean J YoderJose R Conejo-GarciaJose A Guevara-PatinoMarcelo BonomiPriyanka BhatejaJames W RoccoConor E SteuerNabil F SabaChristine H Chung
Published in: Journal for immunotherapy of cancer (2022)
Our data suggest that, despite the great clinical heterogeneity of HNSCC and the limited responders in the present cohort, the peripheral TCR repertoires from pretreatment PBMC may be developed as biomarkers for the benefit of immunotherapy in HNSCC.
Keyphrases
  • peripheral blood
  • locally advanced
  • single cell
  • regulatory t cells
  • electronic health record
  • big data
  • metastatic colorectal cancer
  • squamous cell carcinoma
  • immune response
  • high throughput sequencing
  • dendritic cells