The Arg/Arg genotype of leptin receptor gene Gln223Arg polymorphism may be an independent risk factor for nonalcoholic fatty liver disease.
Mahsa NavariFatemeh ZareiShiva SayedsalehiTouraj MahmoudiMitra RostamiAidin MahbanGholamreza RezamandAsadollah AsadiReza DabiriHossein NobakhtHamid FarahaniSeidamir Pasha TabaeianMohammad Reza ZaliPublished in: Laboratory medicine (2024)
We found that the LEPR Gln223Arg Arg/Arg genotype was independently associated with a more than 2-fold rise in biopsy-proven NAFLD risk. Our findings, however, need to be corroborated by further studies.