An Open-Source, Automated Tumor-Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer.

Yalai BaiKimberly ColeSandra Martinez-MorillaFahad Shabbir AhmedJon ZugazagoitiaJohan StaafAna BoschAnna EhingerEmma NimeusJohan Hartman Balazs Acs David L Rimm

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Neural net-driven cell classifier-defined TIL variables were robust and independent prognostic factors in several independent validation cohorts of TNBC patients. These objective, open-source TIL variables are freely available to download and can now be considered for testing in a prospective setting to assess clinical utility.See related commentary by Symmans, p. 5446.

Keyphrases

prognostic factors
end stage renal disease
machine learning
deep learning
newly diagnosed
ejection fraction
chronic kidney disease
single cell
high throughput
peritoneal dialysis
peripheral blood
neural network