The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats.

Shi Young ChungJinyoung KimHong Bum BaeTran Duc TinWan JuSang-Hyun Kwak

Published in: Acute and critical care (2018)

Collectively, these findings indicate that flecainide acetate can improve survival in a rat sepsis model by attenuating LPS-induced neutrophil responses. We therefore suggest that flecainide acetate plays an important role in modulating inflammatory-immune responses.

Keyphrases

lps induced
immune response
inflammatory response
oxidative stress
acute kidney injury
toll like receptor
dendritic cells
intensive care unit
signaling pathway
type diabetes
risk factors
septic shock
coronary artery disease
free survival