Bedaquiline exposure in pregnancy and breastfeeding in women with rifampicin-resistant tuberculosis.

Richard CourtKamunkhwala GausiBuyisile MkhizeLubbe WiesnerCatriona WaittHelen McIlleron Gary Maartens Paolo DentiMarian Loveday

Published in: British journal of clinical pharmacology (2022)

We report low exposure of bedaquiline in pregnant women treated for rifampicin-resistant TB. Bedaquiline significantly accumulates in breast milk; breastfed infants receive mg/kg doses of bedaquiline equivalent to maternal doses.

Keyphrases

drug resistant
multidrug resistant
mycobacterium tuberculosis
pregnant women
pulmonary tuberculosis
pregnancy outcomes
preterm infants
preterm birth
hiv aids
newly diagnosed